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The present study was aimed to develop chitosan-coated enamel adhesive device of CAP-P 407 (Cellulose acetate phthalate-Poloxamer 407), loaded with MNC (Minocycline) for sustained release and site-specific drug delivery system for the carious lesion. The average tensile strength and  in-vitro  drug release of uncoated dental film were found to be 15.97 kg/mm 2  and 98.11% in 24 h, respectively. The average  in-vitro  mucoadhesion time and tooth adhesion strength of the finished product was found to be 249 minutes and 268 g, respectively.  In-vitro  antimicrobial study showed the drug concentration is well above MIC even after 8 hours of drug release.

international journal of polymeric materials and polymeric biomaterials

Development and quality evaluation of chitosan-coated cellulose acetate phthalate-poloxamer enamel adhesive device for the treatment of dentin carious lesion