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In the present study, to advance the skin tissue regeneration process, aspirin (AS)-loaded polycaprolactone (PCL) and maltodextrin (MD) composite nanofiber was prepared via electrospinning technique. The results showed that the composite had more uniform nanofibers and the mean diameter of the nanofibers was reduced from 186 to 96 nm experimentally with increasing AS percentages. Biological evaluations proved that L929 fibroblast cells on the PCL/MD with 2% AS had better cell adhesion and proliferation. The overall results introduce that 2% AS incorporated in the PCL/MD electrospun nanofibers can be applied as a promising candidate for further studies toward skin tissue regeneration.

In vitro and in vivo study of aspirin loaded, electrospun polycaprolactone–maltodextrin membrane for enhanced skin tissue regeneration