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Nanofibrous scaffold was electrospun by blending PCL and gelatin. Nanofibers were bead-free and showed homogenous morphology with an average diameter of 320 ± 80 nm. Different concentrations of curcumin were loaded in PLA microparticles in the electrospraying process. Particles showed spherical morphology and the average diameter of 3.7 µm. The scaffold was electrospun using two-nozzles in which PLA particles sprayed among PCL/gelatin nanofibers. Finally, the scaffold was cross-linked via glutaraldehyde vapor. A very slow release manner was seen in the release profile within 35 days. Mechanical properties and cell assessment study showed that the scaffold has great potential for skin application.

An investigation into curcumin release from PLA particles loaded in PCL-GELATIN fibers for skin application