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Effects of  Lepidium sativum  and  Curcuma longa  were investigated on pharmacokinetics and pharmacodynamics of antihypertensive drug (amlodipine).Hypertensive rats were treated with amlodipine,  Lepidium sativum ,  Lepidium sativum  + amlodipine,  Curcuma longa  and  Curcuma longa  + amlodipine, and their blood pressures were measured. Amlodipine in plasma samples was analysed using UPLC-TQD. Product ions of amlodipine were monitored at m/z 409.18 &gt; 238 and 409.18 &gt; 294, and of nitrendipine at m/z 361.16 &gt; 315.1 and 361.16 &gt; 329.10.Lepidium sativum  + amlodipine treatment showed highest reduction in systolic blood pressure (SBP). Mean anti-hypertensive effect of  Lepidium sativum  and  Curcuma longa  was similar to amlodipine. Mean SBPs (1–24 h) of amlodipine,  Lepidium sativum ,  Lepidium sativum  + amlodipine,  Curcuma longa  and  Curcuma longa  + amlodipine-treated animals were found as 149.5 ± 2.4 mmHg, 151.6 ± 1.09 mmHg and 141.8 ± 2.5 mmHg, 154.9 ± 2.2 mmHg and 144.4 ± 2.6 mmHg ( p -value ≤0.05), respectively.  Lepidium sativum  and  Curcuma longa  significantly increased amlodipine C max  by 83% ( p -value 0.018) and 53% ( p -value 0.035), and AUC 0–t  by 48% ( p -value &gt;0.05) and 56% (p-value 0.033), respectively.Results of pharmacokinetic and pharmacodynamic studies are in agreement.  Lepidium sativum  and  Curcuma longa  augment antihypertensive effect of amlodipine, which is also supported by pharmacokinetic observations. Effects of  Lepidium sativum  and  Curcuma longa  were investigated on pharmacokinetics and pharmacodynamics of antihypertensive drug (amlodipine). Hypertensive rats were treated with amlodipine,  Lepidium sativum ,  Lepidium sativum  + amlodipine,  Curcuma longa  and  Curcuma longa  + amlodipine, and their blood pressures were measured. Amlodipine in plasma samples was analysed using UPLC-TQD. Product ions of amlodipine were monitored at m/z 409.18 &gt; 238 and 409.18 &gt; 294, and of nitrendipine at m/z 361.16 &gt; 315.1 and 361.16 &gt; 329.10. Lepidium sativum  + amlodipine treatment showed highest reduction in systolic blood pressure (SBP). Mean anti-hypertensive effect of  Lepidium sativum  and  Curcuma longa  was similar to amlodipine. Mean SBPs (1–24 h) of amlodipine,  Lepidium sativum ,  Lepidium sativum  + amlodipine,  Curcuma longa  and  Curcuma longa  + amlodipine-treated animals were found as 149.5 ± 2.4 mmHg, 151.6 ± 1.09 mmHg and 141.8 ± 2.5 mmHg, 154.9 ± 2.2 mmHg and 144.4 ± 2.6 mmHg ( p -value ≤0.05), respectively.  Lepidium sativum  and  Curcuma longa  significantly increased amlodipine C max  by 83% ( p -value 0.018) and 53% ( p -value 0.035), and AUC 0–t  by 48% ( p -value &gt;0.05) and 56% (p-value 0.033), respectively. Results of pharmacokinetic and pharmacodynamic studies are in agreement.  Lepidium sativum  and  Curcuma longa  augment antihypertensive effect of amlodipine, which is also supported by pharmacokinetic observations.

xenobiotica

Herb–drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of  Lepidium sativum  and  Curcuma longa