English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Native skin consists mainly of epidermal and dermal layers. Here in this work, we have constructed an artificial skin scaffold mimicking the bilayered structure of the native skin using electrospinning technique for wound healing. Polyurethane (PU) and Gelatin (Ge) were used for developing the epidermal layer and the dermal layer respectively. Ciprofloxacin HCl (Cip. HCl) a fluoroquinolone antibiotic was incorporated in both the layers for rapid wound healing. Morphology of the skin scaffold was studied using scanning electron microscopy (SEM) analysis and the chemical characterization was performed using FTIR spectroscopy. Water vapor transmission rate test and oxygen transmission rate test was conducted to evaluate the barrier properties of the scaffold. Thermal stability of the skin scaffold was evaluated using DSC and TGA while an understanding of the exudate absorbing capacity and degradation behavior of the scaffold was obtained from water absorption studies and  in vitro  degradation studies respectively.  In vitro  drug release study and drug release kinetics was explored to understand the release mechanism of Cip. HCl from the scaffold. Both the layers showed nano and micropores when analyzed using SEM. The dermal layer showed comparatively more water absorption capacity and degradation, hence providing a moist environment for the wound. The skin scaffold was permeable to water vapor and oxygen, and hence will speed up the process of wound healing.  In vitro  release for Cip. HCl showed a non-Fickian swelling type release with zero-order kinetics. Disk diffusion test conducted on the bilayers proved the antibacterial activity of the membrane. Hence the electrospun PU-Ge skin scaffold containing Cip. HCl is a promising candidate among modern day wound healing materials.

Electrospun polyurethane-gelatin artificial skin scaffold for wound healing