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Synthesis of 2-aryl substituted benzoxazoles, benzothiazoles, and quinoxalinones  via  decarboxylative coupling of α-keto acids with 2-aminophenol, 2-aminothiophenol, and OPD ( o -phenylenediamine), using K 2 CO 3  as a base in water at room temperature, and as well as solvent-free grinding and the synthesis of benzoxazinones from the reaction of α-keto acids with 2-aminophenol at 60 °C have been reported. Both the protocols afforded a wide range of desired products with excellent functional group tolerance in yields of 87–99%. The major advantages of these approaches are catalyst-free protocol, short reaction times, straightforward workup, and chromatography-free processing of the products. Additionally, to test the translational demand of this methodology, the synthesis of 2-(3,5-dichlorophenyl)-6-methylbenzo[ d ]oxazole was carried out which is a key structure of tafamidis, a commercially available drug.

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Base promoted coupling of α-ketoacids and 2-substituted aromatic amines: Green synthesis of diverse benzoxazoles, benzothiazoles, quinoxalinones and benzoxazinones and its practical application