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A series of amide tagged 1,4-disubstituted 1,2,3-triazole has been designed and synthesized in good yield through Cu (I) catalyzed click chemistry strategy. The synthesized triazoles were characterized by various spectral techniques like FT-IR,  1 H NMR,  13 C NMR, and high-resolution mass spectrometery. The synthesized amide-tagged disubstituted triazoles were assessed for  in vitro  antimicrobial activity against two Gram-positive bacteria-  Staphylococcus aureus ,  Bacillus subtilis ; two Gram-negative bacteria-  Escherichia coli ,  Klebsiella pneumonia  and two fungi- Candida albicans ,  Aspergillus niger . Most of the synthesized compounds displayed good activity, among these, compound  6 m,  4-((1-(4-nitrophenyl)-1 H -1,2,3-triazol-4-yl)methoxy)benzamide and compound  6t,  2-(4-((1-(4-nitrophenyl)-1 H -1,2,3-triazol-4-yl)methoxy)phenyl)acetamide with MIC values 0.020 and 0.017 µmol/mL respectively revealed appreciable efficacy against tested microbial strains. Further, molecular docking study also disclosed that docked compounds  6 m  and  6t  bound efficiently with the active site of receptor  S. aureus DNA gyrase .

Design, synthesis, characterization and antimicrobial evaluation of amide tagged 1,4-disubstituted 1,2,3-triazoles