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A series of hesperetin derivatives were synthesized by  Williamson  etherification,  Steglich  esterification and ring-opening by modifying the 7 hydroxyl group, 3’ hydroxyl group and C ring of hesperetin. All compounds were confirmed by IR,  1 H NMR,  13 C NMR and HR-MS. The antioxidant activity of hesperetin derivatives was tested by ABTS method.  Hp-1 ,  Hp-2(b,d) ,  Hp-3 ,  Hp-5 ,  Hp-6(a-d)  and  Hp-7(a-c)  had antioxidant effects, and  Hp-7a  had the strongest antioxidant effect, which was better than the positive control quercetin, and the TEAC value was 4.62 mM.  Hp-2b ,  Hp-3 ,  Hp-7b  and  Hp-7c  hesperetin derivatives had inhibitory effects on tyrosinase, and were superior to α-arbutin positive control.  Hp-2b  had the best inhibitory effect on tyrosinase, and the IC 50  value was 0.657 ± 0.093 mmol·L −1 .

Synthesis, characterization, antioxidant and tyrosinase inhibitory activities of hesperetin derivatives