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A new set of pyrazolo[1,5- a ]pyrimidines  5–8  and imidazo[1,2-b]pyrazoles  9–11  incorporating isoxazole as pharmacologically attractive cores were synthesized starting with aminopyrazole derivative  4 . Moreover, the treatment of arylidine derivative  3  with hydroxylamine hydrochloride as nucleophilic reagent afforded the isoxazole derivative  12 . All the new target derivatives were assessed  in vitro  antimicrobial candidates against six strains (three Gram + ve Bacteria and three Gram -ve Bacteria) and two fungi. Target compounds  4, 5, 6, 9  and  10  illustrated potent activity against some of the pathogens compared to the reference drug Ampicillin with minimum inhibitory concentration (MIC) values in some cases less than the reference the other derivatives represented moderate to week and in some cases inactive as a compound  8 . Compounds  4, 5, 6  and  10  showed moderate activity against fungi. Finally, antioxidant activities were performed for the most promising targets (except  3a,b  and  8 ) which displayed moderate to very strong antioxidant activities.

Synthesis, antimicrobial and antioxidant activities of some new pyrazolo[1,5- a ]pyrimidine and imidazo[1,2- b ]pyrazole derivatives based isoxazole