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A new bunch of substituted aryl amino derivatives structurally modified pyrido[3,2-d]pyrimidines ( 10a–j)  have been synthesized and evaluated for anticancer effects against PC3 (human prostate), A549 (human lung), MCF-7 (human breast) and Colo-205 (human colon) cancer cell lines by utilizing of MTT procedure. Most of the synthesized compounds were showed anticancer activity good to moderate activities with IC 50  values range from 0.013 ± 0.0058 µM to 8.22 ± 5.87 µM, whereas, standard 9 etoposide used as standard drug) showed IC 50  values from 0.14 ± 0.017 µM to 3.08 ± 0.135 µM, respectively. Among the synthesized compounds, five compounds  10a, 10b, 10c, 10d  and  10e  demonstrated more potent activity on all cell lines. Mainly, compound  10e  displayed higher anticancer activity.

Design, synthesis and biological evaluation of aryl amino derivatives of pyrido [3,2-d]pyrimidines as anticancer agents