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The present work describes an green and eco-friendly synthetic protocol, and  vitro  anti-proliferative activity of a new series of 3-arylidine imidazo[1,2- c ]pyrimidines. The target molecules  4a–p  were synthesized via one-pot cyclization of 6-amino-4-(4-chlorophenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile( 1 ) with chloroacetyl chloride followed by condensation with a series of aromatic and heteroaromatic aldehydes in the presence of K 2 CO 3 -NPs at room temperature. The high yield (80–96%), mild reaction conditions (short reaction time and no heat needed), simple purification, and soft, cheap, high efficiency readily available and stability of K 2 CO 3 -NPs are evident features of the present approach. Pyrimidines  4c, 4 g  and  4i  demonstrated significant anti-proliferative activity against MCF-7 especially compound  4i  was found to be the most effective among the tested compounds with IC 50  values  3.83  µg/ml in MCF-7 cell line compared to the standard drug doxorubicin. In addition, compounds  4b, 4c, 4d, 4i,  and  4n  demonstrated high cytotoxic activity against HCT116, particularly compound ( 4b ) was the most potent among the tested compounds with IC 50  values  9.3  µg/ml in HCT116 cell line compared to doxorubicin.

K 2 CO 3 -nanoparticles catalyzed the synthesis of 3-arylidine imidazo[1,2- c ]pyrimidine candidates: Cytotoxic activity and docking study