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Novel fluorescent oxo-fluoro quinoline ( E )-chalcone derivatives were synthesized using a new Aluminum Strontium Titanium Trioxide (Al-SrTiO 3 ) solid catalyst. The Al-SrTiO 3  catalyst was analyzed by spectroscopic techniques like Fourier Transform Infrared (FT-IR), X-Ray Powder Diffraction, absorption, Scanning Electron Microscopy, SEM-Mapping, Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis and Raman spectroscopy. The novel precursors 2-(4-fluorophenoxy)quinoline-3-carbaldehyde derivatives ( 3a ,  3b ) were synthesized from 2-chloro-3-formyl quinoline and were subsequently used to synthesize the oxo-fluoro quinoline-based  E -chalcones derivatives ( 5a–x ). The chemical structure of  5a–x  were investigated by FT-IR,  1 H and  13 C-NMR, 2D-NMR and high-resolution mass spectroscopy. Further, molecular docking studies on the hit compound  5t  indicated hydrogen bond interaction with Bovine Serum Albumin at amino acids Arginine-194, 198 and 217 with bond lengths of 2.1, 2.2 and 2.2 Å, respectively. The calculated Gibbs free energy value was −5.84 kJ mol −1 , while the experimental value of −27.82 kJ mol −1  was obtained from emission spectroscopy.

synthetic communications

Design and development of novel fluorescent oxo-fluoro quinoline ( E )-chalcone derivatives  via  Claisen–Schmidt reaction using Al-SrTiO 3  as a catalyst and its BSA protein binding studies