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In this study novel 2-(4-(1-phenyl-1 H -pyrazol-3-yl)phenoxy)- N -arylacetamide hybrids with fused 1,4-dihydropyridines such as acridines and tetrahydrodipyrazolo[3,4- b :4',3'- e ]pyridines were successfully and efficiently prepared through a one-pot multi-component reaction of 2-(4-(4-formyl-1-phenyl-1 H -pyrazol-3-yl)phenoxy)- N -arylacetamide with dimedone, or 5-methyl-2,4-dihydro-3 H -pyrazol-3-one at reflux. The tri-substituted methanes (TRSMs) were synthesized through the reaction of the appropriate aldehyde with 6-aminothiouracil and 4-hydroxycoumarin. The structures of novel compounds were confirmed based on spectral data.

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Synthesis of novel acridines, tetrahydrodipyrazolo [3,4- b :4',3'- e ]pyridines, tri-substituted methanes (TRSMs) bearing 2-(4-(1-phenyl-1 H -pyrazol-3-yl)phenoxy)- N -phenylacetamide unit as novel hybrid molecules