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A series of new pyrimidine derivatives were synthesized, including sulfapyrimidines and pyrazolo[1,5- a ]pyrimidines. In basic medium, pyrimidine compounds were produced by reacting sulfa guanidine with either 2-cyano-3-(dimethylamino)- N -acrylamides or  N -(4-chlorophenyl)-2-cyano-3-(4-aryl)-acrylamides. The reaction of 5-amino-1 H -pyrazole-4-carboxamides with either 2-cyano-3-(dimethylamino)- N -acrylamides or  N -(4-chlorophenyl)-2-cyano-3-(4-aryl)acrylamides resulted in the synthesis of pyrazolo[1,5- a ]pyrimidine compounds.

Synthesis of new sulfapyrimidine and pyrazolo[1,5- a ]pyrimidine derivatives