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A facile and rapid synthesis of a family of new hybrid system 1,5-disusbtituted 1 H -tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5- a ]pyrazin-6-ones in moderate yields is described. Compounds were synthetized by a high-order multicomponent reaction (MCR) to give  N -acylated 1,5-disubstituted tetrazoles followed, without chromatographic purification, by an SN2/intramolecular [3 + 2] cycloaddition sequence. The target molecules could be useful in drug discovery processes because they contain two very important pharmacophoric moieties: 1,5-disubstituted tetrazole and 1,2,3- triazole.

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Synthesis of novel hybrid 1,5-disusbtituted 1 H- tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5- a ]pyrazin-6-ones  via  high-order MCR-S                     N                  2/intramolecular [3 + 2] cycloaddition sequence