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A convenient approach to the synthesis of 1-aroyl-3,4-dihydro- β -carbolines  via  Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse indolizino[8,7- b ]indole, and pyrido[1,2- a :3,4- b’ ]diindole derivatives has been used. The developed method is a simple and convenient procedure giving medium and excellent yields, showing a wide functional group tolerance.

synthetic communications

Facile synthesis of indolizino[8,7- b ]indole and pyrido[1,2- a :3,4- b’ ]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro- β -carbolines