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In the present study, a series of sulfonamide bridged 1,4-disubstituted 1,2,3-triazoles have been synthesized in good yield  via  click reaction between sulfonamide linked terminal alkynes and  in situ  prepared 2/3/4-azidobenzenesulfonamides. The synthesized triazoles were characterized by FTIR,  1 H NMR,  13 C NMR, and HRMS techniques. Further, all the synthesized compounds were assessed for  in vitro  antibacterial activity against  Staphylococcus aureus ,  Bacillus subtilis ,  Escherichia coli , and  Klebsiella pneumonia . It has been observed that some of the synthesized triazoles possess appreciable efficacy against the bacterial strains used. Particularly, compound 4-bromo- N -((1-(4-(sulfamoylphenyl)-1 H -1,2,3-triazol-4-yl)methyl)benzenesulfonamide  6l  (MIC = 0.132 µmol/mL) revealed significant antibacterial activity against  B. subtilis ,  E. coli , and  K. pneumonia.  Further, the molecular docking study of the above potent compound was also performed in the active site of the enzyme dihydropteroate synthase to have the possible mode of action.

Synthesis and antibacterial evaluation of sulfonamide bridged disubstituted 1,2,3-triazoles