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The molecular hybridization of various compounds with known pharmacological activity is a particularly popular approach for the development of potential drugs with improved pharmacokinetic profiles. In this respect, a novel series of  bis (1,4-dihydropyridine-3,5-dicarbonitrile),  bis (decahydroacridine),  bis (tetrahydrodipyrazolo[3,4-b:4′,3′- e ]pyridin), and  bis (tetrahydropyrimido[4,5- b ]quinoline-2,4,6-trione) derivatives linked to piperazine core  via  phenoxyethanone linkages were prepared  via  Hantzsch like reaction of the ((piperazine-1,4-diyl bis (2-oxoethane-2,1-diyl)) bis (oxy))dibenzaldehydes, with the appropriate active methylene containing reagents. Attempted synthesis of the target products  via bis -alkylation of the appropriate phenol with 1,1′-(piperazine-1,4-diyl) bis (2-chloroethan-1-one) in different basic conditions were unsuccessful.

synthetic communications

Hantzsch-like three-component synthesis of  bis (1,4-dihydropyridines) and  bis (fused-1,4-dihydropyridines) linked to piperazine core  via  2-phenoxyethanone linkage: Novel hybrid molecules