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This review presents a vast body of literature on various synthetic methodology, biological, and fluorescence activities of pyrrolo[3,4‑ c ]coumarins as published during the last 20–30 years. Synthesized pyrrolo[3,4‑ c ]coumarins have been reported in the literature by the construction of either pyrrole, indole, or both rings  via  different synthetic methodology including metal-catalyzed reactions, and green reaction protocols starting from readily accessible substrates.

A short review on the synthesis of pyrrolo[3,4- c ]coumarins an isolamellarin-B scaffolds