English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

An efficient method is reported to prepare functionalized carbazoles in excellent yields under mild conditions through microwave-assisted Pd-catalyzed aryl C–H activation of 2-iodo- N -arylanilines. The use of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a base is found advantageous. Microwave is found beneficial to shorten the reaction time, improve yield, and reduce the amount of base and solvent consumption. Moreover, it offers the access to 4-acetylcarbazole, which was not obtained under conventional heating conditions. Interactions of carbazoles with calf-thymus DNA are investigated by monitoring the change in their photophysical properties. Experimental results hint that the dominant mode of binding of carbazoles with ct-DNA is groove binding in nature and thermodynamically favorable. The highest binding interaction is observed for 4-acetylcarbazole, and the reason behind unequal interactions for different carbazoles can be rationalized by considering the nature and position of functional groups at carbazoles which can affect H-bonding and hydrophobic interactions. Experimental results are in good agreement with molecular docking results.

synthetic communications

Microwave-assisted synthesis of functionalized carbazoles  via  palladium-catalyzed aryl C–H activation and study of their interactions with calf-thymus DNA