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An approach for the synthesis of pyrazolo[4,3-c]quinoline derivatives has been developed by the combination of pyrazole-arylamines and β-keto esters via cleavage of C–C bonds. The strategy shows good tolerance and compatibility with a wide range of functional groups. Moreover, this method features simple conditions, generates a series of alkyl substituted pyrazolo[4,3-c]quinoline, and provides the desired products in moderate to good yields.

Acid-promoted synthesis of pyrazolo[4,3-c]quinoline derivatives by employing pyrazole-arylamines and β-keto esters via cleavage of C–C bonds