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A convenient and efficient reduction of 3-nitro-4-hydroxy-1-methylquinolin-2(1 H )-one using tin and hydrochloric acid produced the novel 3-amino-4-hydroxyquinolinone derivative. The aminoquinoline was reacted with various electrophilic reagents such as acid anhydrides, acyl chlorides and esters to give a tricyclic system namely; oxazoloquinolinone and oxazinoquinolinone. Diazotization and alkylation of aminoquinoline were carried out affording the interesting  N -alkylated quinoline and azodye derivatives. Selected products were screened for their anticancer activity against HepG-2 and MCF-7 cell lines. Among the various synthesized derivatives, the aminoquinoline compound is the strong antiproliferative agent and may consider a specific therapeutic index.

Synthesis and anticancer activity of oxazolo and oxazinoquinolinone derivatives