English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The present work describes the synthesis of novel  ortho -,  meta - and  para -(2-benzo[ d ]oxazolyl)phenyl-β-lactams  5  using isomeric ( ortho -,  meta - and  para -) (2-beno[ d ]oxazolyl)phenyl Schiff bases  4 . The exclusive formation of  trans  configured β-lactams  5  by utilizing O-alkyl/O-aryl substituted acids have been investigated along with the diversified substrate scope and mechanistic enlightenment of the reaction. The relative  trans  configuration of the C-3 and C-4 protons in products  5  was examined using coupling constant value ranging from  J  = 1.4 to 2.6. We described here the stereoselective synthesis of  trans  β-lactams via  ortho-/meta-/para -(2-benzo[d]oxazolyl)phenyl imines and Bose-Evans ketenes which reports generally the  cis  β-lactams in literature. The characterization of the synthesized products  4  and  5  was done by using various spectroscopic techniques viz. FT-IR, NMR ( 1 H,  13 C), elemental analysis (CHN), mass spectrometry ( 4g  and  5c ) and single crystal X-ray crystallography of the representative analogues  4g ,  5c  and  5e .

synthetic communications

Stereoselective synthesis, characterization and mechanistic insights of  ortho -/ meta -/ para -(2-benzo[ d ]oxazolyl)phenyl substituted  trans -β-lactams: Potential synthons for variegated heterocyclic molecules