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2,4,5-Triaryl-1 H -imidazole hybrids were synthesized from substituted benzil and indole-3-aldehyde which on subsequent treatment with aryl azides converted to 1,2,3-triazoles by employing click chemistry. All the synthesized hybrids were characterized by FTIR,  1 H-NMR,  13 C-NMR spectroscopy and HRMS. These scaffolds were tested  in vitro  for their antifungal evaluation against different  candida  species. Screening against the used fungal strains, the results outcome that imidazole-indole hybrids bearing antifungals more effectively reduced than imidazole-indole-1,2,3-triazole hybrids with their MIC 80  values in the range of 2–128 µg/mL. Among all the synthesized hybrids,  2a  and  2b  were found to be the most potent against fungal strains as a result of different methods like, time kill assays, effect on fungal membrane and antibiofilm activity. The docking simulations of the most active hybrids,  2a ,  2b  and  2c  were carried out in the active site of sterol 14-alpha demethylase enzyme of  Candida albicans .

N-Heterocycles hybrids: Synthesis, antifungal and antibiofilm evaluation