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A new library of different substituted aryl derivatives of isoxazole-pyrazolo[1,5-a]pyrimidine ( 10a–j ) were prepared, confirmed their structures by  1 HNMR,  13 CNMR and mass spectral data. Furthermore, the preliminary anticancer activities of newly developed compounds ( 10a–j ) were tested against four human cancer cell lines PC3 (prostate), DU-145 (Prostate), A549 (lung) and MCF-7 (breast) by utilizing of MTT method. The obtained results of were compared with standard reference etoposide. Among all, compounds ( 10a, 10b, 10c, 10e, 10i  and  10j ) displayed highest anticancer activities than standard. Predominantly, one compound  10a  with 3,4,5-trimethoxy substituent on the aryl ring showed excellent activity. The molecular modeling studies indicated the interactions of synthesized compounds with SARM, and DNA via hydrogen bonds and hydrophobic interactions.

Synthesis and biological evaluation of aryl derivatives of isoxazole pyrazolo[1,5-a] pyrimidines as anticancer agents