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( S )-Flurbiprofen ( 1 ) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with osteoarthritis. Herein a new and practical method for the preparation of  1  from 4-bromo-2-fluorobiphenyl ( 2 ) is reported, which achieves a good overall yield (20%) and high enantioselectivity (96%). This method avoids the use of expensive catalysts and affords the possibility of large-scale manufacturing with simple operations.

An efficient method for the synthesis of ( S )-flurbiprofen by 1,2-rearrangement of the aryl group