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To explore the antibacterial activity, a set of new 2-thiobenzyl-3-nitro-imidazo[1,2-a]pyridine derivatives were synthesized ( 9a–h ) and characterized by NMR  1 H,  13 C and high-resolution mass (HRMS). These compounds were obtained by interaction between the 3-nitro-imidazo[1,2-a]pyridine isothiouronium salt ( 7 ) with benzyl chloride or bromide ( 8 ) in the presence of sodium hydroxide (NaOH). Eight ( 9a–h ) of them were evaluated  in vitro  on the positive gram bacterium ( S. aureus  ATCC 29213) and two others negative gram bacteria ( P. aeruginosa  ATCC 27853 and  P. aeruginosa  933 C/21) by methods diffusion in solid medium and liquid macrodilution. Five among the eight compounds ( 9a ,  9d ,  9h ,  9f  and  9g ) showed significant antibacterial activity on  P. aeruginosa  ATCC 27853 and  P. aeruginosa  933 C/21with MIC between 7.81 and 250 µg/mL. All compounds were inactive on  S. aureus . The compounds  9a  and  9g  were more potent on the two strains of  P. aeruginosa  ATCC 27853.

Synthesis and antibacterial activity in vitro of 2-benzylthioimidazo[1,2-a]pyridine derivatives against pathogenic bacterial