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A green and efficient one-pot has been developed for the synthesis of a series of new diethyl-(((2,3-dihydrobenzo[b][1, 4] dioxin-6yl)amino)(substituted phenyl)methyl) phosphonates ( 4a-k ) by the Kabachinik-Fields reaction of 2,3-dihydrobenzo[b] [1, 4]dioxin-6-amine ( 1 ) with various substituted aldehydes ( 2a-k ) and diethyl phosphite ( 3 ) using nano ferrite supported glutathione (nano FGT) as catalyst under microwave irradiation and solvent free conditions. The synthesized compounds were evaluated for their antioxidant (DPPH &amp; FRAP) and anti-inflammatory activity studies. Compounds  4b  (naphthyl) and  4k  (9-anthracenyl) showed highest antioxidant activity than that of standard ascorbic acid in DPPH method. Whereas compounds  4f  (3-nitrophenyl),  4h  (3-phenoxyphenyl) and  4k  (9-anthracenyl) exhibited low IC 50  values than that of standard ascorbic acid in and in Ferric Reducing Antioxidant Power (FRAP) studies. Compounds  4a ,  4b ,  4h ,  4i,  and  4k  have shown strong anti-inflammatory activity against LPS induced cell death in RAW 264.7 cell lines. Molecular docking studies were also carried out against COX-2 showed high binding energies that are in support of their high anti-inflammatory activity. Being the most bioactive compound ( 4k ) stands as promising next future anti-oxidant and anti-inflammatory agent.

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An efficient nano-FGT catalyzed green synthesis of α-aminophosphonates and evaluation of their antioxidant, anti-inflammatory activity and molecular docking studies