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The SARS-CoV-2 pandemic conditioned the optimal timing of some endoscopic procedures. ESGE guidelines recommend replacement or removal of the plastic biliary stents within 3–6 months to reduce the risk of complications. Our aim was to analyse the outcomes of patients who had delayed plastic biliary stent removal following endoscopic retrograde cholangiopancreatography (ERCP) in the pandemic era. Retrospective study including consecutive ERCPs with plastic biliary stent placement between January 2019 and December 2021. Delayed removal was defined as presence of biliary stent &gt;6 months after ERCP. The evaluated outcomes were stent migration, stent dysfunction, obstructive jaundice, cholangitis, acute pancreatitis, hospitalization, and biliary pathology-related mortality. One-hundred and twenty ERCPs were included, 56.7% male patients, with a mean age of 69.4 ± 15.7 years. Indications for plastic biliary stent insertion were choledocholithiasis (72.5%), benign biliary stricture (20.0%), and post-cholecystectomy fistula (7.5%). Delayed stent removal occurred in 32.5% of the cases. The median time to stent removal was 3.5 ± 1.3 months for early removal and 8.6 ± 3.1 months for delayed removal. Patients who had delayed stent removal did not have a significantly higher frequency of stent migration (20.5 vs 11.1%,  p  = 0.17), stent dysfunction (17.9 vs 13.6%,  p  = 0.53), hospitalization (17.9 vs 14.8%,  p  = 0.66), obstructive jaundice (2.6 vs 0.0%,  p  = 0.33), cholangitis (10.3 vs 13.6%,  p  = 0.77), acute pancreatitis (0.0 vs 1.2%,  p  = 1.0), or biliary pathology-related mortality (2.6 vs 1.2%,  p  = 0.55). Delayed plastic biliary stent removal does not seem to have a negative impact on patients’ outcomes. In the current pandemic situation, while scheduled endoscopic procedures may have to be postponed, elective removal of plastic biliary stents can be safely deferred.

Real-life patency of plastic biliary stents in the pandemic era: is stent removal after 6 months safe and effective?