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Endoscopic biopsies can be taken using either single or double bite technique. In the single bite method, intubation time may be proportionately prolonged depending upon the number of biopsies taken. In contrast to this, double bite, though a greater number of biopsies may be taken per unit time, it may influence the quality of the biopsy specimen. The aim of the study was to compare these methods and to see if taking double bite has significant effect on the histological quality of the endoscopic biopsies. A prospective, randomised and partly blind study ( n  = 135, M: 54%, age 21–91 years) divided into two equal arms to compare 144 procedures was conducted. Specimen were compared for time taken to size, depth, crush artefacts, necrosis, fragmentation, distortion, and epithelial stripping. Time taken to collect specimens was also recorded in the upper GI procedures. No significant difference was observed in the histological quality of single and double bite specimens ( p  &lt; 0.05). However, DB took significantly less time ( M  = 88.5, SD ± 28.5) as compared to SB ( M  = 180, SD ± 55.9) ( p  &lt; 0.05). There is no difference between the histological quality of DB and SB and the former technique takes less time, hence reducing intubation time.

One bite or two? A comparison of single bite and double bite bi opsy t echniques in gastrointe s tinal endo s copy (BITES)