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Functional defecation disorder (FDD) is a common subtype of functional constipation (FC). Balloon expulsion test (BET) and high resolution anorectal manometry (HR-ARM) are significant tools but their results are not always consistent. To investigate the characteristics of patients with positive BET and pelvic floor dyssynergia (PFD) and explore the value of both positive results in FDD diagnosis. We retrospectively diagnosed FC subtypes and enrolled FDD patients based on Rome-IV criteria. They underwent HR-ARM, BET and CTT tests. Then they were classified to two groups and further stratified by FDD subtypes. Validated questionnaires were applied to investigate patients’ constipation, anxiety/depression and quality of life. 335 FDD patients were finally enrolled. They were classified into two groups according to whether BET and PFD were both positive (consistent or not). 84.48% showed consistent results. These patients had significantly higher anal residual pressure, lower anal relaxation rate, manometric defecation index (MDI) and a more negative rectoanal pressure gradient (RAPG) ( P s &lt; .05). The specific distribution of FDD phenotypes in two groups showed significant difference ( p  = .021). Males suffered a more negative RAPG ( p  &lt; .001) and age was correlated with anal relaxation rate ( p  &lt; .001). A subset (177 individuals) was investigated with validated questionnaires. Scores for Defecation Symptoms, Physical Discomfort and GAD-7 score were significantly high in Consistent Group ( P s &lt; .05). GAD-7 score was associated with Defecation Symptoms ( p  &lt; .001) while anal residual pressure, GAD-7 and Defecation Symptoms score were linked to Physical Discomfort ( P s &lt; .05). The diagnostic specificity and PPV for FDD rose significantly with positive BET and PFD. FDD patients with positive BET and PFD suffered from severe defecation symptoms, anxiety and impaired QOL. Positive BET and PFD could be an ideal tool for screening FDD.

Clinical value of positive BET and pelvic floor dyssynergia in Chinese patients with functional defecation disorder