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The adipokines adiponectin and leptin play key roles in human metabolic regulation and have gained great attention as biomarkers for various metabolic pathologies. Though, pediatric reference values are few and needed. This study aims to establish age- and sex-specific adipokine reference percentiles based on healthy Danish school children. Further, it elucidates sex-specific differences in associations between z-scores of examined adipokines and metabolic variables. Serum adiponectin and serum leptin from 853 observations of healthy Danish schoolchildren aged 8–17 years (median 10.0) were quantified by immunoassays. Age- and sex-specific adipokine reference percentiles were calculated cross-sectionally using the LMS method, and adipokine z-scores were calculated from the fitted model. Multiple linear regression models were used to examine sex-specific differences in associations between adipokine z-scores and various metabolic variables. Girls had a higher median value of adiponectin (11.31  vs.  10.65 μg/mL,  p  &lt; .001) and leptin (2.30  vs.  1.00 ng/mL,  p  &lt; .001) and a lower median value of adiponectin/leptin ratio (4.64  vs.  10.76,  p  &lt; .001) compared to boys. Sex-specific differences were found in associations between adiponectin z-score and HDL ( p  = .010), between leptin z-score and waist circumference z-score ( p  = .027) and LDL ( p  = .048), and between adiponectin/leptin ratio z-scores and waist circumference z-score ( p  = .044) and LDL ( p  = .040). Reference percentiles of adiponectin, leptin, and adiponectin/leptin ratio are presented in this paper. To our knowledge, this study is the first to demonstrate sex-specific differences in associations between adipokine z-scores and waist circumference z-score and lipids, respectively in healthy children and adolescents.

Reference serum percentile values of adiponectin, leptin, and adiponectin/leptin ratio in healthy Danish children and adolescents