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The existence of predisposing effects of latent  Toxoplasma gondii  ( T. gondii ) infection in bipolar disorder (BD), major depression (MD), and even suicide attempt (SA) has long been debatable. This conjecture remains unclear because there is a lack of evidence regarding how  T. gondii  manipulates the brain and behavior. We investigated the influence of  T. gondii  infection on BD and MD patients with or without SA compared to age-, sex-, and province-matched healthy controls (HCs) concurrently with serology and molecular-based evaluations. We prospectively assessed 147 volunteers with BD, 161 with MD, and 310 HCs. T. gondii  seropositivity rates were 57.1% for BD, 29.2% for MD, 64.8% for SA, and 21.3% for HC. Binary logistic regression analyses revealed that  T. gondii  positive Immunoglobulin G (IgG) status may be a prominent tendentious agent for BD (OR = 3.52; 95% CI [2.19–5.80]; p &lt; 0.001) and SA (OR = 17.17; 95% CI [8.12–36.28]; p &lt; 0.001), but not for MD (OR = 1.21; 95% CI [0.74–1.99]; p = 0.45). Nevertheless, the  T. gondii  DNA ratios determined by polymerase chain reaction (PCR) were linked to BD and MD. Our findings strongly support the burgeoning interest in the possibility that latent  T. gondii  infection may be relevant to the etiology of BD and SA, although this connection remains ambiguous.

Are bipolar disorder, major depression, and suicidality linked with Toxoplasma gondii ? A seromolecular case-control study