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No study has evaluated the impact of written and visual resources in addition to information provided by healthcare workers on the acceptance of the HPV vaccine, which is the focus of the present research. This prospective study was conducted between September 2020 and June 2021. The first group (Group 1) was given a 20-minute informative talk by professional healthcare providers about the benefits of HPV vaccination. For Group 2, the talk from the professional healthcare worker was supplemented with a 1200-word, three-page written information source about the HPV vaccine that was given to patients. In Group 3, participants again received information from professional healthcare providers, supplemented with video content. One week after the first visit, participants’ acceptance status of the HPV vaccination and concerns about the administration of HPV vaccine were reevaluated. At the end of the study period, 225 participants (75 for each group) were enrolled. After the education protocol, concerns about the HPV vaccination significantly decreased in Group 3 in compared with the other groups (p = 0.001). The HPV vaccine acceptance rate increased from 26.7% to 56.0% in group 1, from 24.0% to 58.7% in group 2, and from 28.0% to 82.7% in group 3 (p = 0.001). The present study showed that information from the video supplementing the professional health worker’s talk was associated with significantly lower anxiety and concern level about the HPV vaccine, and significantly higher the HPV vaccine acceptance rate.

Effects of information sources in HPV vaccine acceptance: prospective randomized trial