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Sulfasalazine is a BSC class 4 poorly soluble sulphonamide, and the objective of this work is to employ cosolvents, surfactants, and pH change to improve its solubility. Cosolvents including ethanol, 1,2-propanediol, glycerol, methanol, acetone, and polyethylene glycol (PEG) 400 were utilised to study drug solubility in aqueous solvent mixtures. The effect of surfactant micellization is also investigated using cationic, anionic, and non-ionic surfactants. Moreover, some cosolvency models were used to represent the results as a mathematical model. PEG-400 created the highest enhancement in drug solubility and caused a 317-fold increase relative to its aqueous solubility. Results of the micellization study indicate that the drug is most efficiently dissolved in cationic surfactant followed by anionic surfactant, and it is least dissolved by non-ionic surfactant. Computational modelling shows good reliability of the combined nearly ideal binary solvent/Redlich–Kister and the Jouyban–Acree models for solubility prediction in the binary solvent mixtures.

The effect of cosolvents and surfactants on the solubility of sulfasalazine