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Solubility and density profiles for 3-aminosalicylic acid (3-ASA) in the mixed solvents of 2-propanol and water is determined by a shake-flask method at 293.2–313.2 K. The obtained numerical data is correlated by some mathematical models such as van’t Hoff, the mixture response surface, Jouyban–Acree, Jouyban–Acree–van’t Hoff and the modified Wilson models. The accuracy of the used models is investigated by calculation of the mean relative deviations for back-calculated data. Moreover, apparent thermodynamic properties such as standard enthalpy, Gibbs free energy and entropy of the 3-ASA dissolution process are computed and discussed. Further, 3-ASA is preferentially solvated by water in almost all the aqueous mixtures.

Solubility of 3-aminosalicylic acid in 2-propanol + water mixtures at different temperatures