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The keratin-associated proteins (KAPs) are structural components of wool and hair fibres, with over 90 genes that encode these proteins having been identified in mammalian species. A KAP gene called  KRTAP27-1  was recently identified in goats, but the gene has not been reported in the closely related ruminant species sheep. In this study, we used a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis to find ovine  KRTAP27-1  and investigate nucleotide sequence variation in the gene. Our analysis revealed four sequence variants (named  A  to  D ) in 399 New Zealand Merino × Southdown-cross sheep. Within these sequence variants there were five single nucleotide polymorphisms (SNPs) in the coding region, including two non-synonymous SNPs. Six genotypes ( AA, AB, AC, BB, BC  and  BD ) of  KRTAP27-1  were detected, and for the three genotypes with a frequency of over 5.0%, sheep of genotypes  AB  and  BB  produced wool of higher mean staple length (MSL) and higher greasy fleece weight (GFW) than sheep of genotype  AA . These results suggest that variation in ovine  KRTAP27-1  may be affecting wool growth and thus production.

Identification of the KAP27-1 gene in sheep and its effect on wool traits