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1. Myxovirus resistance (Mx) is a protein produced by the interferon-induced natural immune response with broad spectrum antiviral function. However, the role and expression characteristics of the  Mx  gene in immune defence against viral infection in goose have not yet been reported. 2. This study found a 2576 bp genomic sequence and a 2112 bp mRNA sequence for  Mx , encoding 703 amino acids. Multiple sequence alignments of the amino acid sequences showed that the Yangzhou goose Mx (goMx) had 86.99% similarity to the mallard duck ( Ana s  platyrhynchos ). 3. Tissue-specific expression profiling revealed that the expression of  goMx  was highest in the lung and spleen. Both poly (I:C) and GPV were found to elevate the expression of  goMx . The upregulated expression of  goMx  was associated with interferon pathway-related genes  IRF7 ,  JAK1 ,  STAT1 , and  STAT2 . Furthermore, overexpression of  goMx  significantly activated the transcription of poly (I:C) induced  TNF-α ,  IL-1β ,  IL-6 , and  IL-18 . 4. The findings of this study suggest that the  goMx  modulation of the antiviral response is mediated by the interferon pathway.

Molecular cloning and expression analysis of Myxovirus resistance gene in Yangzhou goose ( Anser cygnoides domesticus)