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Molecular motors are nanometer scale proteins involved in various intracellular processes such as cargo transport, muscle contraction and cell division. The steps in the chemo-mechanical cycle that use ATP hydrolysis to generate motion along the cytoskeletal tracks can be characterized by stepping rates depending only on the current state, permitting modeling of the cycle as a Markov process. To learn more about the nature of motor motion, cell researchers have conducted  in vitro  experiments in which molecular motors pull beads along filaments attached to glass slides and their velocity and run length until detachment from the microtubule are recorded. A formula is derived for distance traveled until detachment. Four molecular motors for which there are run length and velocity measurements in the literature are considered. In each case the derived formulas for run length and velocity have a generalized Michaelis–Menten form as functions of ATP concentration. The degrees of the numerator and denominator polynomials increase with the complexity of chemo-mechanical cycle. The degrees of the Michaelis–Menten form determine the maximum number of reaction rates that can be determined from experimental data on run length and velocity, however consistency conditions may reduce this number and restrict which rates can be determined.

Markov modeling of run length and velocity for molecular motors