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Mycoplasma pneumoniae  ( M. pneumoniae ) is a problem affecting the health of children and adolescents worldwide. Thus, there is a pressing need to construct a point-of-care (POC) method for the rapid detection of  M. pneumoniae . In this work, a sensitive dual electrochemical-colorimetric POC sensor was constructed based on reduced graphene oxide (RGO) and a polyaniline (PANI) modified surface for the rapid diagnosis of  M. pneumoniae . The POC sensor showed excellent performance with a sensitivity of 69.78 mV/pH. The pH measurement was minimally affected in the presence of interfering ions and the durability of the electrochemical sensor was 2.54 mV/d. The device was sensitive for  M. pneumoniae  from 10 2  copies/reaction to 10 5  copies/reaction and satisfactorily validated in 18 clinical specimens. The entire nucleic acid extraction and detection process was completed within 30 min which was 9 minutes less than the commercial fluorescence and colorimetric kits. More interestingly, the results were monitored by the electrochemical signal and solution color change. The results are expected to have a positive impact on the quantitative detection of  M. pneumoniae  and allow the rapid diagnosis of  M. pneumoniae  infections.

Sensitive Dual Electrochemical-Colorimetric Point-of-Care (POC) Sensor for the Rapid Detection of Mycoplasma pneumoniae