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Inspired by the enrichment preferences of metal ions for phosphopeptides, a layered assembly method was adopted to introduce hydrophilic polyhydroxy ligands tannic acid (TA) to prepare magnetic bimetal ion-functionalized nanomaterials denoted by Fe 3 O 4 @TA@Ti 4+ /Zr 4+  to provide the comprehensive enrichment of phosphopeptides. Benefiting from the excellent ion immobilization ability and unbiasedness for phosphopeptide enrichment, Fe 3 O 4 @TA@Ti 4+ /Zr 4+  shows excellent properties for the enrichment and identification of global phosphopeptides. The results show that the material possesses high efficiency, outstanding selectivity (the maximum molar ratio β-casein to bovine serum albumin is 1:1000), a low detection limit of 0.4 fmol/μL, and the ability to be recycled at least 10 times. In addition, excellent performance was also demonstrated in the analysis of skimmed milk and human saliva: 13 and 31 phosphopeptides were successfully captured. The results demonstrate that the material has high potential for practical application in phosphoproteomics.

analytical letters

Efficient Enrichment of Global Phosphopeptides Using Magnetic Tannic Acid – Titanium(IV)/Zirconium(IV) Functionalized Spheres as a Novel Sorbent for Immobilized Metal Ion Affinity Chromatography (IMAC)