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Dexrazoxane is a drug that protects cancer patients undergoing chemotherapy against heart attacks that may be caused by anthracyclines. However, there is insufficient information about whether taking dexrazoxane increases the risk of developing a new type of cancer. In this study, electrochemical determination of dexrazoxane (Dex) was performed by a graphene oxide (GRPox) based disposable sensor. GRPox was synthesized and characterized by X-ray diffraction (XRD), energy dispersive X-Ray spectroscopy (EDX), and transmission electron microscopy (TEM). The GRPox-modified electrodes provide 25% signal enhancement for dexrazoxane. In this study, a detection limit of 1.24 µg/mL was obtained for dexrazoxane with advantages of disposability, low cost, and easy production.

analytical letters

Electrochemical Determination of Dexrazoxane by Differential Pulse Voltammetry (DPV) Using a Graphene Oxide Nanosheet Modified Pencil Graphite Electrode (PGE)