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Developing simple and effective method for carbohydrate antigen 72-4 (CA72-4) detection is important to achieve the early diagnosis and treat of gastric cancer. In this work, multiwalled carbon nanotubes (MWCNT) were treated with a simple wet-chemistry method to form MWCNT/graphene oxide (MWCNT/GO) core/shell nanohybrids that provide high electron transfer, high dispersibility, and a large surface area to immobilize CA72-4 antibodies (Ab) due to the carboxyl groups on the GO shell. Using ferrocyanide/ferricyanide ([Fe(CN) 6 ] 3−/4− ) as the signaling probe, a simple, label-free and effective electrochemical immunosensing platform was constructed for CA72-4. Upon optimizing the experimental conditions, the simple MWCNT/GO hybrids-based immunosensor showed desirable sensing including a wide linear range and low detection limit. Furthermore, the reproducibility, selectivity and practical applications demonstrated potential value to determine CA72-4 in clinical applications for diagnosing gastric cancer.

analytical letters

Simple and Label-Free Electrochemical Immuno Determination of the Gastric Cancer Biomarker Carbohydrate Antigen 72-4 with a Carbon Nanotube-Graphene Oxide Hybrid as the Sensing Platform and Ferrocyanide/Ferricyanide as the Probe