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SLC26A4  gene mutations related to hearing loss patients can obtain good hearing and speech rehabilitation effects after cochlear implantation (CI). To explore the long-term rehabilitative outcomes of CI in patients with different  SLC26A4  mutation groups. Clinical data of 71 patients with  SLC26A4  gene mutations who received CI in the Second Hospital of Lanzhou University from 2012 to 2015 were retrospectively reviewed. According to the genetic test results, use One-way ANOVA analysis to compare the differences in auditory results, categories of auditory performance (CAP) and speech intelligibility rating (SIR) index questionnaire scores and speech recognition rates among different groups in 4-5 years after CI. Compared with other genotypes of  SLC26A4 , the patients with homozygous mutation of c.919-2A &gt; G in  SLC26A4  had better hearing aid threshold at 500 Hz and better recognition rates of Yangyang words than other monoallelic mutation groups after CI ( p  &lt; .05). The most common hot spot mutation of  SLC26A4  gene is c.919-2A &gt; G. The patients with homozygous mutation of c.919-2A &gt; G in  SLC26A4  gene had partly better hearing and speech rehabilitation than other monoallelic mutation groups after CI.

The effect of SLC26A4 gene mutations on long-term rehabilitative outcomes in cochlear implant patients