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This study aimed to determine the relation between titres of anti- Porphyromonas gingivalis (P. gingivalis)  antibody and rheumatoid arthritis (RA) HLA-DRB1 susceptibility region associated with shared epitope (SE) using the Gregersen’s and de Vries’s classification methods. In this cross-sectional study, results of immunoglobulin G1 (IgG1) and immunoglobulin G2 (IgG2) anti-P. gingivalis antibodies, anti-citrullinated protein antibodies (ACPA), diagnosis for RA, and periodontal disease (PD), and a genetic study of the HLA DRB1 region were obtained from 50 patients with RA and 50 control individuals. Anti- P. gingivalis  antibody levels and PD parameters were similar in control and RA groups. Anti- P. gingivalis  antibodies were not associated with SE or ACPA. There was no association between ACPA and SE. However, de Vries’ classification in RA patients revealed an association between the HLA DRB1 neutral alleles and higher titres of anti- P. gingivalis  antibodies as follows: IgG1 anti- P. gingivalis  ≥ 1:400 ( p  = .039); IgG2 anti- P. gingivalis  ≥ 1:400 with neutral/neutral genotype (N/N), being exclusive for RA ( p  = .008); and IgG2 anti- P. gingivalis  ≥ 1:200 and N/N ( p  = .016). Although no association was found between SE and anti- P. gingivalis  antibodies; according to the de Vries’ classification, there was an existing association between HLA DRB1 neutral alleles, with high titres of IgG anti- P.gingivalis  antibodies for RA, focussing on novel associations between  P.gingivalis  and RA.

Relation between anti- Porphyromonas gingivalis antibody titers and HLA-DRB1 neutral alleles in individuals with rheumatoid arthritis