English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Sir, Waldenström’s macroglobulinaemia is an uncommon B-cell lymphoproliferative disorder, characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy (1). The plasmacytoid cells secrete monoclonal IgM, but a diagnosis of macroglobulinaemia can be made irrespective of IgM concentration. Skin involvement is rare, and most often non-specific, due to blood hyperviscosity and cryoglobulinaemia (2). However, two types of specific cutaneous disease have been described: (i) Cutaneous infiltration which is characterized by diffuse plaques and nodular lesions usually located on the face, but also on the trunk and the proximal extremities (3, 4). (ii) Macroglobulinosis of the skin, which is rarer and represents storage IgM lesions, and is characterized clinically by papules due to dermal IgM deposits on the elbows, knees and buttocks (5, 6). Tumour masses are secondary to a dense cellular infiltration, or to amyloid deposits. We report a case in which tumoral masses were numerous, mainly composed of IgM deposits secondary to in situ excretion.

Tumoral macroglobulinosis of the skin: In situ release of IgM