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Sir, Psoriatic arthritis (PSA) is a manifestation of psoriasis present in up to 20% of patients with psoriasis. Five variants have been described: asymmetrical acute oligoarthritis, distal interphalangeal joint arthritis, rheumatoid arthritis-like symmetrical polyarthritis (which is the commonest form), spondylitis and arthritis mutilans. In the absence of typical cutaneous or nail lesions, PSA is easily confused with other forms of arthritis, especially rheumatoid arthritis (RA). Recently, antibodies directed to a citrullinated cyclic peptide (anti-CCP) have been proposed as a specific marker for RA (1, 2). We addressed the question as to whether anti-CCP antibodies may help to distinguish PSA from RA.

Anti-citrulline Antibodies in Psoriatic Patients with and without Arthritis