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Yamada A. Antineutrophil cytoplasmic autoantibodyanti-thyroperoxidas e antibody in addition to, or, less positive crescentric glomerulonephritis associated with thilikely, instead of MPO-ANCA cannot be excluded. amazole therapy. Nephron 1996; 74: 734–735. Vesiculo-bullous SLE has been reported to respond 6. Cooper D. Antithyroid drugs. N Engl J Med 1984; 311: to dapsone (15). However, in our patient, an early 1353–1362. 7. Yung RL, Richardson BC. Drug-induced lupus. Rheum aggressive treatment with steroid pulse therapy and Dis Clin North Am 1994; 20: 61–86. plasmapheresis was mandatory because of her life8. Hess E. Drug-related lupus. N Engl J Med 1988; 318: threatening clinical condition. The contributory factors, 1460–1462. such as an environmental trigger or an immunological 9. Sato-Matsumura KC, Koizumi H, Matsumura T, factor, for the presence of a serious illness in this patient Takahashi T, Adachi K, Ohkawara A. Lupus erythematosus-like syndrome induced by thiamazole and remain to be elucidated. The mechanism by which propylthiouracil. J Dermatol 1994; 21: 501–507. methimazole induces SLE-like reactions is unclear. 10. Wing SS, Fantus IG. Adverse immunologic eVects of antithyroid drugs. Can Med Assoc J 1987; 136: 121–127. 11. Condon C, Phelan M, Lyons JF. Penicillamine-induced type II bullous systemic lupus erythematosus. Br J REFERENCES Dermatol 1997; 136: 474–475. 1. Alarcon-Segovia D. Drug induced lupus syndromes. Mayo 12. Stankus S, Johnson N. Propylthiouracil-induced hyperClin Proc 1969; 44: 664–681.2. sensitivity vasculitis presenting as respiratory failure. Chest 2. Cush JJ, Goldings EA. Drug induced lupus: clinical spec1992; 102: 1595–1596. trum and pathogenesis. Am J Med Sci 1985; 290: 36–45. 13. Haapala AM, Hyoty H, Parkkonen P, Mustonen J, 3. Kitahara T, Hiromura K, Maezawa A, Ono K, Soppi E. Antibody reactivity against thyroid peroxidase Narahara N, Yano S, et al. Case of propylthiouraciland myeloperoxidase in autoimmune thyroiditis and sysinduced vasculitis associated with anti-neutrophil cytotemic vasculitis. Scand J Immunol 1997; 46: 78–85. plasmic antibody (ANCA); review of the literature. Clin 14. Farsi A, Turchini S, Azzurri A, Domeneghetti MP, Nephrology 1997; 47: 336–340. Passaleva A. Some anti-thyroperoxidase antibodies 4. Kawachi Y, Nukaga H, Hoshino M, Iwata M, Otsuka F. positive sera give a pANCA pattern on ethanol- xed ANCA-associated vasculitis and lupus-like syndrome human neutrophils: cross-reactivity or false positives? caused by methimazole. Clin Exp Dermatol 1995; 20: Autoimmunity 1997; 25: 117–122. 345–347. 15. Yung A, Oakley A. Bullous systemic lupus erythematosus. Aus J Dermatol 2000; 41: 234–237. 5. Hori Y, Arizono K, Hara S, Kawai R, Hara M,

Angiokeratoma of the Scrotum (Fordyce Type) Associated with Angiokeratoma of the Oral Cavity