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Sir, Verruca vulgaris is a benign epithelial hyperplasia caused by human papilloma viruses that causes therapeutic problems, especially in immunocompromised patients. We report here 2 patients on continuous immunosuppressive medication with relapsing warts resistant to topical immunotherapy with diphenylcyclopropenone (DCP). As an alternative, occlusive treatment with 5% imiquimod cream was successfully tried. Imiquimod is a recently introduced immunomodi®er intended for condylomata accuminata.

Potentiating Effect of Imiquimod in the Treatment of Verrucae Vulgares in Immunocompromised Patients