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Recent guidelines recommend the use of a short 0-1h high sensitive cardiac troponin (hs-cTn) algorithm in patients presenting with chest pain at the emergency department (ED). This retrospective observational study evaluates the safety and effectiveness of the new 0-1h hs-cTn I protocol in comparison with the standard 0-3h cTn I protocol for the diagnosis of acute myocardial infarction (AMI). A total of two times 100 consecutive chest pain patients presenting at the ED in November/December 2018 (standard 0-3h cTn I group) and in November/December 2020 (short 0-1h hs-cTn I group) were enrolled. Decision making was based upon validated assay-specific cut-off values. The new 0-1h hs-cTn I protocol had a sensitivity of 100% (95% CI 83.2–100) and a negative predictive value of 100% to rule out AMI. The accuracy of rule-in was slightly lower with a specificity of 92.5% (95% CI 84.4–97.2). The overall protocol accuracy was 94% (95% CI 87.4–97.8) in the short 0-1h hs-cTn I group compared to 88% (95% CI 80.0–93.6) in the standard 0-3h cTn I group ( p -value 0.14). The 0-1h hs-cTn I protocol was associated with a numerically higher rate of early hospital discharge compared to the conventional 0-3h cTn I protocol (47% versus 59%;  p -value 0.09) and with a shorter median length of stay for those patients (mean 316 min versus 289 min;  p -value 0.09). The abbreviated protocol based on the 0-1h hs-cTn I assays is effective and safe for the exclusion of AMI at the ED.

Safety and effectiveness of the short (0-1h) high sensitive troponin protocol in real-life practice